Population Pharmacokinetics of Vancomycin in the Pediatric Cardiac Surgical Population

Pharmacokinetics in pediatric population

Population pharmacokinetics of omeprazole in a random Iranian population

Background: Omeprazole is metabolized predominantly by CYP2C19, a polymorphically expressed enzymes that show marked interindividual and interethnic variation. These variations cause a substantial differences that have been reported in the pharmacokinetics of omeprazole. The aim of the present study was to evaluate the pharmacokinetic parameters of omeprazole in a random Iranian population. Met...

Population Pharmacokinetics of Vancomycin in Thai Patients

Population pharmacokinetics of vancomycin in Thai adult patients was determined by non-linear mixed-effects approach using 319 vancomycin serum concentrations from 212 patients. The data were best fitted by a two-compartment model and it was used to examine the effect of patient characteristics on the vancomycin pharmacokinetics. In the final model, there was a linear relationship between vanco...

Population pharmacokinetics of arbekacin, vancomycin, and panipenem in neonates.

Immature renal function in neonates requires antibiotic dosage adjustment. Population pharmacokinetic studies were performed to determine the optimal dosage regimens for three types of antibiotics: an aminoglycoside, arbekacin; a glycopeptide, vancomycin; and a carbapenem, panipenem. Eighty-three neonates received arbekacin (n = 41), vancomycin (n = 19), or panipenem (n = 23). The postconceptio...

[Cardiac arrest in the pediatric population].

A case of cardiac arrest in a ten year old child that was successfully resuscitated is here presented. The etiological investigation showed an Hypertrophic Cardiomyopathy (HCM). An Implantable Cardioverter Defibrillator (ICD) was placed for secondary profilaxy of Sudden Death (SD). Sudden Death in paediatric age is a rare accident with bad prognosis (survival with no sequel inferior to 5%) and ...